Eicosapentaenoic acid (EPA), endocannabinoids (eCBs), and melatonin play a vital role in the mind-body harmony. EPA is an omega-3 fatty acid that is essential for maintaining a healthy brain and nervous system. eCBs are a group of signaling molecules that modulate a wide range of physiological and cognitive processes. Melatonin is a hormone that regulates sleep- wake cycles and circadian rhythms. The effects of EPA, eCBs, and melatonin on mental and medical diseases suggest that fine-tuning these molecules can be a powerful strategy for promoting mind-body health. For example, increasing EPA levels through diet or supplementation may be beneficial for mental health, sleep, and circadian rhythms. Additionally, targeting the eCB system with natural compounds or pharmaceuticals may offer a new approach to treating a wide range of mind-body disorders. This presentation discusses our latest translational research in depression with EPA, eCBs, and melatonin, and their implications for providing insights in daily lifestyle interventions. 5 Selected References: 1. Wen J et al. Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function. Brain Behav Immun. 2024;115:335-355. 2. Yang B et al. Clinical Efficacy and Biological Regulations of ω-3 PUFA-Derived Endocannabinoids in Major Depressive Disorder. Psychother Psychosom. 2019;88(4):215-224. 3. Yang CP et al. Long COVID and long chain fatty acids (LCFAs): Psychoneuroimmunity implication of omega-3 LCFAs in delayed consequences of COVID-19. Brain Behav Immun. 2022 Jul;103:19-27. 4. Borsini A..., Su KP, Pariante CM. Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis. Mol Psychiatry. 2021 Nov;26(11):6773-6788. 5. Satyanarayanan SK..., Su KP. Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety. Brain Behav Immun. 2020;85:142-151.

Kuan-Pin Su is the Deputy Superintendent of An-Nan Hospital in Tainan, and the Professor of Psychiatry and Neurosciences of College of Medicine and the Director of Mind- Body Interface Research Center (MBI-Lab) at the China Medical University (CMU) in Taichung, Taiwan. After graduation from Kaohsiung Medical College in 1995 (MD degree), he received his psychiatry residency training at Taipei City Psychiatric Centre. In 2008, he received his PhD and became the Honorary Faculty of the Institute of Psychiatry-King's College London. Prof Su's team focuses on Translational Brain Research, which connects bedside to bench with novel interdisciplinary approaches of AI technology, neuroimages, genomic, randomizedcontrolled trials (RCTs), cellular and molecular biology, by integrating basic sciences and clinical significance (e.g. pharmaceuticals, nutraceuticals, phytochemicals, acupuncture, photobiomodulation and transcranial magnetic stimulation). Prof Su is a pioneer in nutritional psychiatric research. He is the founding president of Taiwanese Society of Nutritional Psychiatry Research (TSNPR), and one of the five founding committee members and now the Vice President of International Society of Nutritional Psychiatry Research (ISNPR). He is a Board Director of the International Society for the Study of Fatty Acids (ISSFAL) and an Associate Editor of the Brain, Behavior, and Immunity (BBI). He has received prestigious research awards from professional societies, including the NARSAD Young Investigator Award (USA, 2008-2010), Psychopharmacology Award from the British Association for Psychopharmacology (2013), ISSFAL Early Career Award (2016), and Taiwan MoST Outstanding Research Award (ORA) (2019). Prof Su has been actively involved in international academic societies and is an opinion leader in the field of nutritional psychiatry. In the future, Prof Su and his colleagues at the MBI-Lab will keep looking for the novel remedy for depression and the understanding to interface for mind and body.