Virtual Conference
Mental Health 2022

Lucas Manarte

University of Lisbon, Portugal

Title: Executive functions and insight in OCD: a comparative study


Introduction: Around 25% to 30% of patients with obsessive-compulsive disorder (OCD) do not respond to treatment. These patients have the longest duration of disease and the worst prognosis. Following years of research on this topic, insight has emerged as a potential explanation for this therapeutic resistance. Therefore, it has become important to characterize OCD patients with poor insight. Few studies have focused on the neuropsychological and cognitive characteristics of these patients. 
Methods: To help fill this gap, we divided 57 patients into two groups, one with good insight and the other with poor insight, assessed their neuropsychological functions—through a Rey’s figure test, a California verbal learning test, a Toulouse–Piéron test and a Wisconsin Card Sorting Test (WCST)—and compared the results with those of a paired control group. 
Results: The statistical analysis, with a significance level of 95%, revealed differences in the executive function tests, and particularly in the WCST (p ? 0.001) and trail-making-test (TMT A/B) (p 0.002). 
Conclusions: These differences suggest that the neuropsychological profile of poor-insight patients is different from their good-insight counterparts, emphasize the role played by the executive functions in insight and highlights the need for more accurate neurocognitive research and treatment. 


Lucas Manarte is a Psychiatrist since 2014 and has completed his PhD at the age of 40 years from University of Lisbon (UL), Portugal, co-supervised by Prof. Sahakian from Cambridge University. 
He is professor of clinical Psychiatry at U.L. and work in Liaison Psychiatry in a general hospital. He has done research in OCD and insight, and has helped to bring light to the importance  of insight in the study of mental disorders in general and OCD in particular